Gene
atp1b2b
- ID
- ZDB-GENE-010718-1
- Name
- ATPase Na+/K+ transporting subunit beta 2b
- Symbol
- atp1b2b Nomenclature History
- Previous Names
-
- cb712 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable ATPase activator activity. Acts upstream of or within several processes, including inner ear development; posterior lateral line neuromast hair cell differentiation; and startle response. Predicted to be located in membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including fin; heart; otic epithelium; pronephric duct; and sensory system. Orthologous to human ATP1B2 (ATPase Na+/K+ transporting subunit beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb712 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wang et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2197 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12895 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12906 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13292 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20490 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sodium/potassium-transporting ATPase subunit beta | Sodium/potassium-transporting ATPase subunit beta superfamily |
|---|---|---|---|
|
UniProtKB:A0A8M2BCP7
|
283 | ||
|
UniProtKB:Q90Z34
|
292 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp1b2b-201
(1)
|
Ensembl | 2,432 nt | ||
| ncRNA |
atp1b2b-002
(1)
|
Ensembl | 429 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-89J23 | ZFIN Curated Data | |
| Encodes | EST | cb712 | (3) | |
| Encodes | cDNA | MGC:73035 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131838 (1) | 2533 nt | ||
| Genomic | GenBank:CR854980 (1) | 82050 nt | ||
| Polypeptide | UniProtKB:Q90Z34 (1) | 292 aa |
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Liu, H., Chen, Y., Hu, W., Luo, Y., Zhu, P., You, S., Li, Y., Jiang, Z., Wu, X., Li, X. (2022) Impacts of PFOAC8, GenXC6, and their mixtures on zebrafish developmental toxicity and gene expression provide insight about tumor-related disease. The Science of the total environment. 858(Pt 2):160085
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Chen, X., Li, W. (2021) Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio). The Science of the total environment. 787:147529
- Hu, S.Q., Xu, H.M., Qian, F., Chen, C.S., Wang, X., Liu, D., Cheng, L. (2021) Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis. Developmental Neurobiology. 82(1):88-97
- Tao, Y., Yang, Y., Jiao, Y., Wu, S., Zhu, G., Akindolie, M.S., Zhu, T., Qu, J., Wang, L., Zhang, Y. (2020) Monobutyl phthalate (MBP) induces energy metabolism disturbances in the gills of adult zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 266:115288
- Esbaugh, A.J., Brix, K.V., Grosell, M. (2019) Na+ K+ ATPase isoform switching in zebrafish during transition to dilute freshwater habitats. Proceedings. Biological sciences. 286:20190630
- Wu, Y., Zhang, Y., Chen, M., Yang, Q., Zhuang, S., Lv, L., Zuo, Z., Wang, C. (2019) Exposure to low-level metalaxyl impacts the cardiac development and function of zebrafish embryos. Journal of environmental sciences (China). 85:1-8
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Li, X., Song, G., Zhao, Y., Zhao, F., Liu, C., Liu, D., Li, Q., Cui, Z. (2017) Claudin7b is required for the formation and function of inner ear in zebrafish. Journal of Cellular Physiology. 233(4):3195-3206
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