Gene

cry3b

ID

ZDB-GENE-010426-5

Name

cryptochrome circadian regulator 3b

Symbol

cry3b Nomenclature History

Previous Names

cry1bb
cry2b
cry3b (1)
zcry2b (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Involved in negative regulation of transcription, DNA-templated. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Is expressed in brain; eye; integument; and pleuroperitoneal region. Orthologous to human CRY1 (cryptochrome circadian regulator 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cry3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Delayed sleep phase disorder, susceptibility to}	614163

Associated With cry3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005101	Cryptochrome/DNA photolyase, FAD-binding domain
Domain	IPR006050	DNA photolyase, N-terminal
Family	IPR002081	Cryptochrome/DNA photolyase class 1
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR036134	Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily
Homologous_superfamily	IPR036155	Cryptochrome/photolyase, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Cryptochrome/DNA photolyase class 1	Cryptochrome/DNA photolyase, FAD-binding domain	Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily	Cryptochrome/photolyase, N-terminal domain superfamily	DNA photolyase, N-terminal	Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:A0A8M3AXA7 InterPro	640
UniProtKB:A0A8M1PCZ5 InterPro	639
UniProtKB:A0A8M9P4C5 InterPro	639

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cry1bb-202 (1) Ensembl	Ensembl	2,550 nt	Select Tool ZFIN BLAST
mRNA	cry3b-201 (1) Ensembl	Ensembl	3,057 nt	Select Tool ZFIN BLAST
mRNA	cry3b-205 (1) Ensembl	Ensembl	1,917 nt	Select Tool ZFIN BLAST
mRNA	cry3b-206 (1) Ensembl	Ensembl	1,920 nt	Select Tool ZFIN BLAST
mRNA	cry3b-207 (1) Ensembl	Ensembl	3,377 nt	Select Tool ZFIN BLAST
mRNA	cry3b-208 (1) Ensembl	Ensembl	3,460 nt	Select Tool ZFIN BLAST
ncRNA	cry1bb-002 (1) Ensembl	Ensembl	1,068 nt	Select Tool ZFIN BLAST
ncRNA	cry1bb-003 (1) Ensembl	Ensembl	922 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations