Gene

cry1a

ID

ZDB-GENE-010426-2

Name

cryptochrome circadian regulator 1a

Symbol

cry1a Nomenclature History

Previous Names

cry1a
cry1aa
zcry1a (1)
zgc:153885

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Involved in several processes, including entrainment of circadian clock; negative regulation of transcription, DNA-templated; and response to hydrogen peroxide. Localizes to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Is expressed in brain; eye; integument; and kidney. Orthologous to human CRY1 (cryptochrome circadian regulator 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 20 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cry1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Delayed sleep phase disorder, susceptibility to}	614163

Associated With cry1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005101	Cryptochrome/DNA photolyase, FAD-binding domain
Domain	IPR006050	DNA photolyase, N-terminal
Family	IPR002081	Cryptochrome/DNA photolyase class 1
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR036134	Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily
Homologous_superfamily	IPR036155	Cryptochrome/photolyase, N-terminal domain superfamily