Gene
ncoa2
- ID
- ZDB-GENE-010406-3
- Name
- nuclear receptor coactivator 2
- Symbol
- ncoa2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Exhibits thyroid hormone receptor binding activity. Involved in chordate embryonic development; granulocyte differentiation; and primitive hemopoiesis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is expressed in several structures, including eye; gill; integument; liver; and pleuroperitoneal region. Orthologous to human NCOA2 (nuclear receptor coactivator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu757 (1 image)
- af323989 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Zhuravleva et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR010011 | Nuclear receptor coactivator, DUF1518 |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013767 | PAS fold |
| Domain | IPR014920 | Nuclear receptor coactivator, Ncoa-type, interlocking |
| Domain | IPR014935 | Nuclear receptor coactivator, receptor-binding domain |
| Domain | IPR028822 | Nuclear receptor coactivator 2, basic helix-loop-helix |
| Domain | IPR032565 | Nuclear receptor coactivator 2/3, DUF4927 |
| Family | IPR017426 | Nuclear receptor coactivator |
| Homologous_superfamily | IPR009110 | Nuclear receptor coactivator, interlocking |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR037077 | Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily |
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear receptor coactivator | Nuclear receptor coactivator 2/3, DUF4927 | Nuclear receptor coactivator 2, basic helix-loop-helix | Nuclear receptor coactivator, DUF1518 | Nuclear receptor coactivator, interlocking | Nuclear receptor coactivator, Ncoa-type, interlocking | Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily | Nuclear receptor coactivator, receptor-binding domain | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q98TW1
|
1505 | |||||||||||||
|
UniProtKB:E7F5J8
|
1505 | |||||||||||||
|
UniProtKB:A0A8M9PG56
|
1504 | |||||||||||||
|
UniProtKB:F6NH98
|
1435 |
Interactions and Pathways
No data available
Plasmids
No data available