Gene
cldn1
- ID
- ZDB-GENE-010328-11
- Name
- claudin 1
- Symbol
- cldn1 Nomenclature History
- Previous Names
-
- cldn19 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have structural molecule activity. Predicted to localize to bicellular tight junction; integral component of membrane; and plasma membrane. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Is expressed in eye and ovary. Orthologous to human CLDN1 (claudin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis | 607626 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Claudin | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|
|
UniProtKB:Q90XQ8
|
210 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Kollmar, et al. 2001. (Proc. Natl. Acad. Sci. 98:10196-10201.; ZDB-PUB-010912-21) originally suggested this gene was the ortholog of human CLDN19 based on amino acid sequence similarity. Subsequent analysis suggests it is the ortholog of human CLDN1 and mouse Cldn1.