Gene
cyp11a1.1
- ID
- ZDB-GENE-010306-1
- Name
- cytochrome P450 family 11 subfamily A member 1, tandem duplicate 1
- Symbol
- cyp11a1.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol monooxygenase (side-chain-cleaving) activity. Acts upstream of or within several processes, including C21-steroid hormone biosynthetic process; epiboly; and positive regulation of microtubule polymerization. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including brain; endocrine system; interrenal primordium; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 51 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb957 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb156 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| ihb157 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa38075 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3907 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| zf3908 | Allele with one deletion | Unknown | Premature Stop | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital adrenal insufficiency | Alliance | Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete | 613743 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, families 11 and 27 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7SYJ6
|
509 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp11a1-201
(1)
|
Ensembl | 2,185 nt | ||
| mRNA |
cyp11a1-202
(1)
|
Ensembl | 2,235 nt | ||
| mRNA |
cyp11a1-203
(1)
|
Ensembl | 833 nt | ||
| mRNA |
cyp11a1-204
(1)
|
Ensembl | 776 nt | ||
| mRNA |
cyp11a1-205
(1)
|
Ensembl | 884 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-91C1 | ZFIN Curated Data | |
| Encodes | EST | cb957 | Thisse et al., 2001 | |
| Encodes | EST | fj97d10 | ||
| Encodes | cDNA | MGC:66431 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174439 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152953 (1) | 2212 nt | ||
| Genomic | GenBank:AL929050 (1) | 196743 nt | ||
| Polypeptide | UniProtKB:Q7SYJ6 (1) | 509 aa |
- Li, Y., Li, X., Ye, D., Zhang, R., Liu, C., He, M., Wang, H., Hu, W., Sun, Y. (2024) Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zoological research. 45:176188176-188
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Chen, A.Q., Xue, M., Qiu, C.Z., Zhang, H.Y., Zhou, R., Zhang, L., Yin, Z.J., Ren, D.L. (2023) Circadian clock1a coordinates neutrophil recruitment via nfe212a/duox-reactive oxygen species pathway in zebrafish. Cell Reports. 42:113179113179
- Liao, X., Tao, B., Zhang, X., Chen, L., Chen, J., Song, Y., Hu, W. (2023) Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology. 576:112010
- Arab-Bafrani, Z., Zabihi, E., Hoseini, S.M., Sepehri, H., Khalili, M. (2022) Silver nanoparticles modify hypothalamic-pituitary-interrenal axis and block cortisol response to an acute stress in zebrafish, Danio rerio. Toxicology and industrial health. 38(4):201-209
- Chen, X., Zheng, J., Zhang, J., Duan, M., Xu, H., Zhao, W., Yang, Y., Wang, C., Xu, Y. (2022) Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior. The Science of the total environment. 838(Pt 1):155610
- Duan, M., Guo, X., Chen, X., Guo, M., Xu, H., Hao, L., Wang, C., Yang, Y. (2022) Life Cycle Exposure to Cyhalofop-Butyl Induced Reproductive Toxicity in Zebrafish. Toxics. 10(9)
- Kolas, V., Mathieu, G., Wu, Y.T., Chung, B.C. (2022) Evaluation of two gene ablation methods for the analysis of pregnenolone function in zebrafish embryonic development. Biochemical and Biophysical Research Communications. 636:84-88
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Valdivieso, A., Anastasiadi, D., Ribas, L., Piferrer, F. (2022) Development of epigenetic biomarkers for the identification of sex and thermal stress in fish using DNA methylation analysis and machine learning procedures. Molecular Ecology Resources. 23(2):453-470
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