Gene
gdnfa
- ID
- ZDB-GENE-010226-1
- Name
- glial cell derived neurotrophic factor a
- Symbol
- gdnfa Nomenclature History
- Previous Names
-
- gdnf
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Exhibits MAP kinase kinase kinase activity. Involved in enteric nervous system development and protein-containing complex assembly. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Is expressed in several structures, including brain; digestive system; eye; intermediate mesoderm; and lateral line system. Orthologous to human GDNF (glial cell derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
{Hirschsprung disease, susceptibility to, 3} | 613711 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
Domain | IPR047020 | Glial cell line-derived neurotrophic factor, TGF-beta-like domain |
Family | IPR016649 | Glial cell line-derived neurotrophic factor |
Family | IPR043401 | Glial cell line-derived neurotrophic factor family |
Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
Protein | Length | Cystine-knot cytokine | Glial cell line-derived neurotrophic factor | Glial cell line-derived neurotrophic factor family | Glial cell line-derived neurotrophic factor, TGF-beta-like domain | Transforming growth factor-beta, C-terminal |
---|---|---|---|---|---|---|
UniProtKB:Q98TU0
|
235 | |||||
UniProtKB:A7E220
|
235 |
Interactions and Pathways
No data available
Plasmids
No data available