Gene
fgf8b
- ID
- ZDB-GENE-010122-1
- Name
- fibroblast growth factor 8b
- Symbol
- fgf8b Nomenclature History
- Previous Names
-
- fgf17
- fgf17a
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have fibroblast growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; nervous system development; and positive regulation of cell division. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Is expressed in several structures, including anterior macula; brain; midbrain hindbrain boundary neural rod; optic vesicle; and otic vesicle. Orthologous to human FGF8 (fibroblast growth factor 8).
- Genome Resources
- Note
-
Reifers et al. (2000) originally reported this gene as fgf17a with synteny to Mmu Fgf17. Kikuta et al. (2007) present mapping data showing fgf17a (fgf8b) as syntenic to Hsa Chr. 1. These data, along with BLAST results, led to changing fgf17a to fgf8b.
- Comparative Information
-
- All Expression Data
- 18 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu586 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 6 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 6 with or without anosmia | 612702 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|
|
UniProtKB:B3DJ36
|
212 | ||
|
UniProtKB:Q805B2
|
212 |
Interactions and Pathways
No data available
Plasmids
No data available