Gene
pcxb
- ID
- ZDB-GENE-000831-1
- Name
- pyruvate carboxylase b
- Symbol
- pcxb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable pyruvate carboxylase activity. Acts upstream of or within response to cadmium ion. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; and musculature system. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sandoval et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026197Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12351 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21111 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34211 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pyruvate carboxylase deficiency disease | Alliance | Pyruvate carboxylase deficiency | 266150 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001882 | Biotin-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR000891 | Pyruvate carboxyltransferase |
| Domain | IPR003379 | Carboxylase, conserved domain |
| Domain | IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
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Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | ATP-grasp fold | ATP-grasp fold, subdomain 1 | Biotin-binding site | Biotin carboxylase, C-terminal | Biotin carboxylase-like, N-terminal domain | Biotin carboxylation domain | Biotin/lipoyl attachment | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Carboxylase, conserved domain | Pre-ATP-grasp domain superfamily | Pyruvate carboxylase | Pyruvate carboxyltransferase | Rudiment single hybrid motif | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QYZ6
|
1181 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194C5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-46D17 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-52E12 | ZFIN Curated Data | |
| Contains | SNP | rs3728105 | ZFIN Curated Data | |
| Contains | SNP | rs3728106 | ZFIN Curated Data | |
| Contains | SNP | rs3728107 | ZFIN Curated Data | |
| Contains | SNP | rs3728108 | ZFIN Curated Data | |
| Contains | SNP | rs3728109 | ZFIN Curated Data | |
| Contains | SNP | rs3728110 | ZFIN Curated Data | |
| Contains | SNP | rs3728111 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131550 (1) | 5619 nt | ||
| Genomic | GenBank:AL772193 | 192531 nt | ||
| Polypeptide | UniProtKB:F1QYZ6 (1) | 1181 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Delgadillo-Silva, L.F., Tsakmaki, A., Akhtar, N., Franklin, Z.J., Konantz, J., Bewick, G.A., Ninov, N. (2019) Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Disease models & mechanisms. 12(1):
- Liu, H., Wang, X., Wu, Y., Hou, J., Zhang, S., Zhou, N., Wang, X. (2018) Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings. Environmental pollution (Barking, Essex : 1987). 246:414-422
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Fei, F., Sun, S.Y., Yao, Y.X., Wang, X. (2017) [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Sheng li xue bao : [Acta physiologica Sinica]. 69:61-69
- Sandoval, I.T., Delacruz, R.G., Miller, B.N., Hill, S., Olson, K.A., Gabriel, A.E., Boyd, K., Satterfield, C., Remmen, H.V., Rutter, J., Jones, D.A. (2017) A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).. eLIFE. 6
- Nguyen, V.T., Fuse, Y., Tamaoki, J., Akiyama, S.I., Muratani, M., Tamaru, Y., Kobayashi, M. (2016) Conservation of the Nrf2-Mediated Gene Regulation of Proteasome Subunits and Glucose Metabolism in Zebrafish. Oxidative medicine and cellular longevity. 2016:5720574
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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