Gene

zic2a

ID

ZDB-GENE-000710-4

Name

zic family member 2 (odd-paired homolog, Drosophila), a

Symbol

zic2a Nomenclature History

Previous Names

zic2.1 (1)
zic2 (1)
cb851 (1)
fb26a03
wu:fb26a03

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; neural tube formation; and regulation of signal transduction. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Is expressed in several structures, including anterior neural keel; central nervous system; ectoderm; neural plate; and presumptive structure. Orthologous to human ZIC2 (Zic family member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

42 figures from 25 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb851 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 18 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zic2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
holoprosencephaly 5	Alliance	Holoprosencephaly 5	609637

Associated With zic2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR041643	ZIC protein, zinc finger domain
Family	IPR050329	GLI C2H2-type zinc-finger
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily