Gene
apaf1
- ID
- ZDB-GENE-000616-4
- Name
- apoptotic peptidase activating factor 1
- Symbol
- apaf1 Nomenclature History
- Previous Names
-
- zgc:136543
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activator activity involved in apoptotic process. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c. Predicted to localize to cytosol. Orthologous to human APAF1 (apoptotic peptidase activating factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001315 | CARD domain |
| Domain | IPR002182 | NB-ARC |
| Domain | IPR037963 | Apoptotic Protease-Activating Factor 1, CARD domain |
| Domain | IPR041452 | APAF-1 helical domain |
| Domain | IPR048975 | Apoptotic protease-activating factor 1, winged-helix domain |
| Family | IPR017251 | Apoptotic protease-activating factor 1 |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR042197 | Apoptotic protease-activating factors, helical domain |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Length | APAF-1 helical domain | Apoptotic protease-activating factor 1 | Apoptotic Protease-Activating Factor 1, CARD domain | Apoptotic protease-activating factor 1, winged-helix domain | Apoptotic protease-activating factors, helical domain | CARD domain | Death-like domain superfamily | G-protein beta WD-40 repeat | NB-ARC | P-loop containing nucleoside triphosphate hydrolase | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9I9H8
|
1261 | |||||||||||||||
|
UniProtKB:A0A8M2BC28
|
1261 |
Interactions and Pathways
No data available
Plasmids
No data available