Gene
caspa
- ID
- ZDB-GENE-000616-3
- Name
- caspase a
- Symbol
- caspa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables Pyrin domain binding activity and cysteine-type endopeptidase activity. Involved in self proteolysis. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; innate immune response; and pyroptosis. Part of inflammasome complex. Is expressed in several structures, including digestive system; heart; hematopoietic system; integument; and male organism. Orthologous to several human genes including CASP4 (caspase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016129 | Peptidase family C14A, His active site |
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
| Domain | IPR004020 | DAPIN domain |
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Domain Details Per Protein
| Protein | Length | Caspase-like domain superfamily | DAPIN domain | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9I9L7
|
383 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225P5 | ZFIN Curated Data | |
| Encodes | EST | fa93b02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109869 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191955 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131505 (1) | 1533 nt | ||
| Genomic | GenBank:BX649388 (1) | 177865 nt | ||
| Polypeptide | UniProtKB:Q9I9L7 (1) | 383 aa |
No data available
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Xu, F.H., Qiu, Y.Z., Zhang, Y., Yang, F.H., Ji, M.M., Liu, K.C., Jin, M., Zhang, S.S., Li, B. (2023) The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish. Food & function. 14(13):6157-6171
- Niu, L., Luo, G., Liang, R., Qiu, C., Yang, J., Xie, L., Zhang, K., Tian, Y., Wang, D., Song, S., Takiff, H.E., Wong, K.W., Fan, X., Gao, Q., Yan, B. (2022) Negative Regulator Nlrc3-like Maintain the Balanced Innate Immune Response During Mycobacterial Infection in Zebrafish. Frontiers in immunology. 13:893611
- Shkarina, K., Hasel de Carvalho, E., Santos, J.C., Ramos, S., Leptin, M., Broz, P. (2022) Optogenetic activators of apoptosis, necroptosis, and pyroptosis. The Journal of cell biology. 221(6):
- Chen, W., Zhao, J., Mu, D., Wang, Z., Liu, Q., Zhang, Y., Yang, D. (2021) Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 206(8):1913-1922
- Matsui, H., Ito, J., Matsui, N., Uechi, T., Onodera, O., Kakita, A. (2021) Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease. Nature communications. 12:3101
- Molagoda, I.M.N., Athapaththu, A.M.G.K., Choi, Y.H., Park, C., Jin, C.Y., Kang, C.H., Lee, M.H., Kim, G.Y. (2021) Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production. Antioxidants (Basel, Switzerland). 10(8):
- Angileri, K.M., Gross, J.M. (2020) dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye. Scientific Reports. 10:11293
- Frame, J.M., Kubaczka, C., Long, T.L., Esain, V., Soto, R.A., Hachimi, M., Jing, R., Shwartz, A., Goessling, W., Daley, G.Q., North, T.E. (2020) Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell. 55(2):133-149.e6
- Mai, Y., Peng, S., Li, H., Gao, Y., Lai, Z. (2020) NOD-like receptor signaling pathway activation: A potential mechanism underlying negative effects of benzo(α)pyrene on zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 240:108935
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