Genomic Feature
tw204
- ID
- ZDB-ALT-980203-1354
- Name
- tw204
- Synonyms
-
- AW04A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one MNV (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- MNV
- Variant Location
- Chr 10: 31337726 - 31337727 (GRCz11) (1) Details
- Nucleotide change
- GA/TT
- Variant Notes
-
This feature is composed of two adjacent nucleotide changes, T2099A and C2100A.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AAGTACGCACAGTTGCAAAGCCAGTCAAATATACTGTGTAAAATAGTCACGTAAAACAAATTTACCAAGAAAACCTAGAGTGTAGAATAATTTAATAATTCATGAAAAATACATCCCCTCCAAATAAGACAGAGTTCTCCAGCCTATGTCTGTAATTCAATTGCAGAACACCAATACACTTGCTATTAATTTGGATCTCTGGCAGTAGCTTGGTGCCTGAGGGAGTGATTCTTGCATGGGGCCGGATGTAAGGATATATTTGCCCTCGCATGACTGTGAGGAGCAATAGAGCAAGCAGGACGAGGTCAGGGACGGGCCAAATATTACCCCCGTCTATCACGGCCGAGCAGCCACGCTAAGACAGTGACACTGGATTAATAAAAAATGAAGAATGGACTCCAGCTGAAGCCTCAGGCGAAAGACAATGTTATCTAGGAGCGGGGGGAAAACAAACAGGAATGGAGCAGAACGGAGATGTTTGCTGTGTAGTTTACTGACCT
GA/TT AGGCCTCGATGATGTAAGAGGTGACGGCGGCGCCGCCTTCGTGTGCGTTGGGTTGCCAGGTGAGGGTGACACTGTTACGGGTTACATCCGTTACGACAGGTTTCTGAGGAGGACCGGGCAGTTGATAGGGCTCTGATACCGGAGATGCTGATAGACCACCACTCTCTGTGAAGAGAACATTAGGATTTGATTTCAGTTTTATTATTCACATTTTTAGCTTTAGCAATTTTGCTTATATTGCATTGCTTTGTATTATATTGTAATGTATTGTACTGTATTGTATTAAATTATATTACATTCCGCTGTGGCAATCTCGGATAAATCAGAAACTAAAGCCGAAGGAAAATTAATGAATGAATATTATATTATTATATTATATGTTATGTTGTTATATTATGTTATGTTGTTTTATTATATTATATTATATTATAATATATTATATTATCTTATATTTATAATATTTATTATATTATATTATATTATATTATATAATATTATAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| robo3tw204/tw204 | Homozygous | ♀+/- ♂+/- | 6 figures from 3 publications | Fig. 3 from Burgess et al., 2009 | |
| robo3tw204/+; zc49Tg | Complex | Fig. 5  from Schweitzer et al., 2013 | |||
| robo3tw204/tw204; j1229aGt | Complex | Fig. 4 from Burgess et al., 2009 | |||
| robo3tw204/tw204; zc49Tg | Complex | Fig. 5 from Schweitzer et al., 2013 | Fig. 5 from Schweitzer et al., 2013 | ||
| robo2ti272z/ti272z; robo3tw204/+ | Complex | ||||
| robo2ti272z/ti272z; robo3tw204/tw204 | Complex | ||||
| robo2ti272z/ti272z; robo3tw204/tw204; zc49Tg | Complex | Fig. 8 from Schweitzer et al., 2013 | Fig. 8 from Schweitzer et al., 2013 | ||
| robo3tw204/+; zc49Tg + MO2-sim1a | Complex | Fig. 5 from Schweitzer et al., 2013 | |||
| robo3tw204/tw204; zc49Tg + MO2-sim1a | Complex | Fig. 5 from Schweitzer et al., 2013 | |||
| robo2ti272z/ti272z; robo3tw204/+; zc49Tg + MO2-sim1a | Complex | Fig. 8 from Schweitzer et al., 2013 | Fig. 8 from Schweitzer et al., 2013 |
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Supplemental Information
- Genotyping protocol
- None
- Schweitzer, J., Löhr, H., Bonkowsky, J.L., Hübscher, K., and Driever, W. (2013) Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism. Development (Cambridge, England). 140(1):93-106
- Burgess, H.A., Johnson, S.L., and Granato, M. (2009) Unidirectional startle responses and disrupted left-right co-ordination of motor behaviors in robo3 mutant zebrafish. Genes, brain, and behavior. 8(5):500-511
- Kastenhuber, E., Kern U., Bonkowsky, J.L., Chien, C.B., Driever, W., and Schweitzer, J. (2009) Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(28):8914-8926
- Neuhauss, S.C.F., Biehlmaier, O., Seeliger, M.W., Das, T., Kohler, K., Harris, W.A., and Baier, H. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(19):8603-8615
- Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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