Genomic Feature
dmh4
- ID
- ZDB-ALT-180319-25
- Name
- dmh4
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Matthew Harris Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 24: 40042203 (GRCz11) (1) Details
- Nucleotide change
- G/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>T (1)
- Transcript Consequence
- Nonsynonymous (1)
- Protein Consequence
- Amino Acid Substitution: Ile>Leu at position 156 (1)
- Flanking Sequence
-
TTATGTAATTATTAATTATATTTGTAGTTATATGTATTTATTAATTATAATTAAATATTAAATGTATGTAATACTAATTATTTAATATGTAATGTAATTATAACATTTCAAATGAATGCTATTTAAATATTAAATTAATTATATTAAGTATGTTTTGTTATGAATTATTTGTTAATTAATTGTAGGTTTTTGTTATTATTATTATTATTATTATTATTATTATTATTATTAATTCTATGTAACCTGCCAATCTGGCAACTTTCCCTATTATTTGTTGAACATATAAATAAGGAACACACTCCCATAAACATGTATAATTATTAGAGAGAAAAAATCTGTAATAGTTAATTATAATTTGTGTTGTGTGTGTCCAGCGGTGCAGTGCTCTGGGGGTCAGGTGTATCAGGAGTGCGGGCGTCTGTGCGGGACGTCCTGTGCTGATCTGTGGGACGGCTGGAGCTGTGAGCCGGACGAGGGCAGCAGGGTGTGTGTTTCGGGTT
G/T TCAGTGTCCTGATGGACTGGCGCAGGACGCTCAGGGTCAGTGTGTGCCCGTCCACATGTGCCCCTGTAAGAGCGGAGACACTCTCCATCCCGCCGGCAGCTCCATAAACAACAACTGCAACACCTGGTAAGTGATCTCAAACTCTCAGTTATGTGTGATGTTGTGTAATATGATGACTGAATTTATTTTTGCTGAATATTTTGCTGATTTTGGCAATAGTATCTGAATGCAGCCTTGATGATGCAAGCTGAGCTGCATACAGTATCTCAGTGATGCAATCTCAGACACTCAATAGAGTTAGTGATGTCACTGTGAGGGGTGGGGTTAGATGAAAATATTGAAATCCATTAGATCACAGGTGTCAAACTCTGTTCCAAAAGGGCCGCAGCTCTGTACAGTTTAGTTCCAACCCTAATTAAACACACCTGATCAAACTAATTGAGTCCTTCAGGCTTGTTTGAAACCTACAGGTAAGTGTGTTGGAGCAGGGTTGGAACTAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sspodmh4/dmh4 | Homozygous | ♀+/- ♂+/- | 2 figures  from Rose et al., 2020 | Fig. 3 from Rose et al., 2020 | |
| sspodmh4/+ | Heterozygous | Unknown | Fig. 3 from Henke et al., 2017 | ||
| sspodmh4/+ | Heterozygous | ♀+/- ♂+/- | 2 figures from Rose et al., 2020 | Fig. 3 from Rose et al., 2020 | |
| sspodmh4/+; gl23Tg; ump5Tg | Complex | Fig. 4 from Rose et al., 2020 | |||
| sspodmh4/+; sspohsc105/+ | Complex | Fig. 2 from Rose et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Meyer-Miner, A., Van Gennip, J.L.M., Henke, K., Harris, M.P., Ciruna, B. (2022) Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model. iScience. 25:105028
- Rose, C.D., Pompili, D., Henke, K., Van Gennip, J.L.M., Meyer-Miner, A., Rana, R., Gobron, S., Harris, M.P., Nitz, M., Ciruna, B. (2020) SCO-Spondin Defects and Neuroinflammation Are Conserved Mechanisms Driving Spinal Deformity across Genetic Models of Idiopathic Scoliosis. Current biology : CB. 30(12):2363-2373.e6
- Henke, K., Daane, J.M., Hawkins, M.B., Dooley, C.M., Busch-Nentwich, E.M., Stemple, D.L., Harris, M.P. (2017) Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form.. Genetics. 207(2):609-623
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