Genomic Feature
s357
Notes
| Comment | Citation |
|---|---|
| s357 has a C->T missense mutation in the nr3c1 (gr, utouto) coding sequence ... | Ziv et al., 2013 |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 14: 23763335 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Arg>Cys at position 443 (1)
- Flanking Sequence
-
AGTAGACTACCTAATTTATATAATATTTTTATATAATATGATTATAATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATTTTTTTTTTTTTTTTTTTTTTTTTTTATATAGATGTATACTTTTAATCCCAAAATTTTTGTTTTGTGAATTTTAGGGAATTACCACCACAAAATCACAAAAAAATAACACGAAAAACTAGGGGTGGGGGAGGGGGGAATTGGGATAAGTTAGTAACACTGATAACCTTTGTTAACAAATATGCATGTTGAACATTACTGAGTGTTATGTTTTCACAAAAAGTTCTATAAATAAAGTTATAAAAAATGTGATTCTCAGTTTATCCACATTTATGCAGCTCTAATATCTAAACTGACATTTAAGGACACACTGGTATAATTATATAATAAATGCAAGATTTCATGTTACCCTCTAGGTTCATGCCTGCCATGAGGCATTTGCGGAAAC
G/A ACAGGCAGGGCAGTTCTTCCGGCGGATTTTGTCAATGATGCAATCGTTTCGCCCAGCACACAGGTAATTGTGTTGCCCTATGAAAAACAAAAAAAGGTAATGATTAGACAGGATGTGTCAAGAGACCCTCACCCTTCACTGCTGTCCAACACTGTTCTGAAACCCACTGCATGGATCTGACTGTTTATGCACAAATGAGAACAACAAACATTTCTGCCACTGTTTTGTTGTAGATCTTCAAATGTATTTAGTTAATTGGCAGACGTTCTTGGTGTTATTTGTCTGCTTGGGAGACATAATCATGATTTCCAGCTAGAAGGATGCATTTCAGCACCCACACAATAAAACATTTTGACTGACGAGTGACTCATTGTACGAGTCATTTGAAGTAGACGTGCTATGAGAAGTCAGATCTTGCTGGAAGGACGTGGTCTCTAACTCTACCTTATTAGGTAAAGAAGCACTAATGGAAAGAAAATCACATGTTGAAATTGCCACTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| nr3c1s357/s357 | Homozygous | ♀+/- ♂+/- | 14 figures from 6 publications | 9 figures  from 5 publications | |
| nr3c1s357/s357 | Homozygous | ♀-/- ♂-/- | Fig. 4 from Facchinello et al., 2017 | 4 figures from 2 publications | |
| nr3c1s357/s357 | Homozygous | Unknown | Fig. 7 from Chatzopoulou et al., 2016 | ||
| nr3c1s357/+ | Heterozygous | Unknown | text only from Chiu et al., 2016 | ||
| nr3c1s357/+ | Heterozygous | ♀+/- ♂+/- | Fig. 1 from Muto et al., 2013 | ||
| nr3c1s357 | Unknown | Unknown | Fig. for (s357) from Phenotype Annotation (1994-2006) | ||
| nr3c1s357/s357; ct830Tg/+ | Complex | text only from Chiu et al., 2016 | |||
| nr3c1s357/s357; g1Tg | Complex | Fig. 4 from Mosser et al., 2019 | |||
| nr3c1s357/s357; ia20Tg | Complex | 2 figures from 2 publications | |||
| nr3c1s357/s357; ia20Tg | Complex | Fig. 3 from Facchinello et al., 2017 |
1 - 10 of 14
Show
Supplemental Information
- Genotyping protocol
- None
- Eachus, H., Oberski, L., Paveley, J., Bacila, I., Ashton, J.P., Esposito, U., Seifuddin, F., Pirooznia, M., Elhaik, E., Placzek, M., Krone, N., Cunliffe, V.T. (2023) Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease models & mechanisms. 16(9):
- Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):
- Gans, I., Hartig, E.I., Zhu, S., Tilden, A.R., Hutchins, L.N., Maki, N.J., Graber, J.H., Coffman, J.A. (2020) Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Scientific Reports. 10:11415
- He, M., Halima, M., Xie, Y., Schaaf, M.J.M., Meijer, A.H., Wang, M. (2020) Ginsenoside Rg1 Acts as a Selective Glucocorticoid Receptor Agonist with Anti-Inflammatory Action without Affecting Tissue Regeneration in Zebrafish Larvae. Cells. 9(5):
- Jaikumar, G., Slabbekoorn, H., Sireeni, J., Schaaf, M., Tudorache, C. (2020) The role of the Glucocorticoid Receptor in the Regulation of Diel Rhythmicity. Physiology & behavior. 223:112991
- Marchi, D., Santhakumar, K., Markham, E., Li, N., Storbeck, K.H., Krone, N., Cunliffe, V.T., van Eeden, F.J.M. (2020) Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae. PLoS Genetics. 16:e1008757
- Sireeni, J., Bakker, N., Jaikumar, G., Obdam, D., Slabbekoorn, H., Tudorache, C., Schaaf, M. (2020) Profound effects of glucocorticoid resistance on anxiety-related behavior in zebrafish adults but not in larvae. General and comparative endocrinology. 292:113461
- Brun, N.R., van Hage, P., Hunting, E.R., Haramis, A.G., Vink, S.C., Vijver, M.G., Schaaf, M.J.M., Tudorache, C. (2019) Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish. Communications biology. 2:382
- Hayward, T., Young, A., Jiang, A., Crespi, E.J., Coffin, A.B. (2019) Glucococorticoid receptor activation exacerbates aminoglycoside-induced damage to the zebrafish lateral line. Hearing Research. 377:12-23
- Mosser, E.A., Chiu, C.N., Tamai, T.K., Hirota, T., Li, S., Hui, M., Wang, A., Singh, C., Giovanni, A., Kay, S.A., Prober, D.A. (2019) Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen. Scientific Reports. 9:12405
1 - 10 of 24
Show