Genomic Feature
hi2639cTg
- ID
- ZDB-ALT-040213-4
- Name
- hi2639cTg
- Synonyms
-
- hi2639c (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the plus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 7: 10701936 - 10701937 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| arnt2hi2639cTg/hi2639cTg | Homozygous | Unknown | Fig. 3 from Kasher et al., 2016 | ||
| arnt2hi2639cTg/hi2639cTg | Homozygous | ♀+/- ♂+/- | Fig. 5  from Blanchet et al., 2017 | ||
| arnt2hi2639cTg/+ (AB) | Heterozygous | Unknown | |||
| arnt2hi2639cTg | Unknown | Unknown | Fig. for (hi2639c) from Phenotype Annotation (1994-2006) | ||
| arnt2hi2639cTg/hi2639cTg; zc49Tg | Complex | Fig. 4 from Schweitzer et al., 2013 |
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Supplemental Information
- Genotyping protocol
- hi2639ctg.pdf
- Blanchet, P., Bebin, M., Bruet, S., Cooper, G.M., Thompson, M.L., Duban-Bedu, B., Gerard, B., Piton, A., Suckno, S., Deshpande, C., Clowes, V., Vogt, J., Turnpenny, P., Williamson, M.P., Alembik, Y., Glasgow, E., McNeill, A. (2017) MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus. PLoS Genetics. 13:e1006957
- Kasher, P.R., Schertz, K.E., Thomas, M., Jackson, A., Annunziata, S., Ballesta-Martinez, M.J., Campeau, P.M., Clayton, P.E., Eaton, J.L., Granata, T., Guillén-Navarro, E., Hernando, C., Laverriere, C.E., Liedén, A., Villa-Marcos, O., McEntagart, M., Nordgren, A., Pantaleoni, C., Pebrel-Richard, C., Sarret, C., Sciacca, F.L., Wright, R., Kerr, B., Glasgow, E., Banka, S. (2016) Small 6q16.1 Deletions Encompassing POU3F2 Cause Susceptibility to Obesity and Variable Developmental Delay with Intellectual Disability. American journal of human genetics. 98(2):363-72
- Schweitzer, J., Löhr, H., Bonkowsky, J.L., Hübscher, K., and Driever, W. (2013) Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism. Development (Cambridge, England). 140(1):93-106
- Löhr, H., Ryu, S., and Driever, W. (2009) Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages. Development (Cambridge, England). 136(6):1007-1017
- Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., Lin, S.Y., Nissen, R.M., and Hopkins, N. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nature Genetics. 31(2):135-140
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