| Phenotype: | blood vasculature hippo signaling increased process quality, abnormal |
|---|---|
| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | blood vasculature |
|---|---|
| Synonyms: | blood vessel |
| Definition: | Is an interconnected tubular multi-tissue structure that contains blood that is actively transported around the organism. |
| Ontology: | Anatomy Ontology [ZFA:0001079] |
| Name: | hippo signaling |
|---|---|
| Synonyms: | hippo signal transduction, hippo signaling cascade, hippo signaling pathway, hippo signalling cascade, Salvador-Warts-Hippo signaling pathway, SWH pathway |
| Definition: | An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation. |
| Ontology: | GO: Biological Process [GO:0035329] QuickGO AmiGO |
| Name: | increased process quality |
|---|---|
| Synonyms: | |
| Definition: | A quality of a process that has a value that is increased compared to normal or average. |
| Ontology: | Phenotypic Quality Ontology [PATO:0002304] |