| Name: |
hypoxia-inducible factor-1alpha signaling pathway |
| Synonyms: |
HIF1alpha pathway,
hypoxia-inducible factor signaling,
hypoxia-inducible factor-1alpha signalling pathway
|
| Definition: |
The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. |
| Ontology: |
GO: Biological Process [GO:0097411]
QuickGO
AmiGO
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