Term Name: | integrin alpha-M |
---|---|
Synonyms: | CD11 antigen-like family member B, CD11b, cell surface glycoprotein MAC-1 subunit alpha, CR-3 alpha chain, CR3A, ITGAM, leukocyte adhesion receptor MO1, neutrophil adherence receptor |
Definition: | An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1. |
Ontology: | Cell Ontology [PR:000001012] |