Term Name: integrin alpha-M
Synonyms: CD11 antigen-like family member B, CD11b, cell surface glycoprotein MAC-1 subunit alpha, CR-3 alpha chain, CR3A, ITGAM, leukocyte adhesion receptor MO1, neutrophil adherence receptor
Definition: An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1.
Ontology: Cell Ontology [PR:000001012]

Relationships
is a type of: integrin alpha with A domain
inverse has_high_plasma_membrane_amount: CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell CD27-high, CD11b-high natural killer cell CD27-low, CD11b-high natural killer cell CD103-negative, langerin-positive lymph node dendritic cell liver CD103-negative dendritic cell lymphoid MHC-II-negative classical monocyte lymphoid MHC-II-negative non-classical monocyte peritoneal macrophage
inverse has_low_plasma_membrane_amount: alveolar macrophage CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell CD27-high, CD11b-low natural killer cell CD27-low, CD11b-low immature natural killer cell CD103-positive, langerin-positive lymph node dendritic cell Kupffer cell liver CD103-positive dendritic cell lymph node macrophage splenic red pulp macrophage
inverse has_plasma_membrane_part: band form neutrophil basophilic metamyelocyte basophilic myelocyte CD11b-positive dendritic cell CD11b-positive, CD27-positive natural killer cell CD115-positive monocyte dermal dendritic cell elicited macrophage eosinophilic metamyelocyte eosinophilic myelocyte epidermal Langerhans cell Gr1-high classical monocyte Gr1-low non-classical monocyte Gr1-positive, CD43-positive monocyte granulocyte interstitial dendritic cell langerin-negative dermal dendritic cell microglial cell monoblast myeloid suppressor cell neutrophilic metamyelocyte neutrophilic myelocyte promonocyte segmented neutrophil of bone marrow
inverse lacks_plasma_membrane_part: basophil progenitor cell CD8_alpha-negative CD11b-negative dendritic cell CD8_alpha-positive CD11b-negative dendritic cell CD11c-low plasmacytoid dendritic cell common dendritic progenitor eosinophil progenitor cell erythroblast erythroid progenitor cell, mammalian group 2 innate lymphoid cell, mouse hematopoietic multipotent progenitor cell hematopoietic oligopotent progenitor cell, lineage-negative hematopoietic stem cell langerin-positive dermal dendritic cell mast cell progenitor megakaryocyte progenitor cell natural helper lymphocyte pre-conventional dendritic cell proerythroblast promyelocyte reticulocyte splenic marginal zone macrophage thymic conventional dendritic cell thymic plasmacytoid dendritic cell