Term Name: | CLOCK-BMAL transcription complex |
---|---|
Synonyms: | CLOCK/BMAL complex |
Definition: | Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms. |
Ontology: | GO: Cellular Component [GO:1990513] QuickGO AmiGO |