Term Name: | Bfa1-Bub2 complex |
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Synonyms: | |
Definition: | A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation. |
Ontology: | GO: Cellular Component [GO:1990334] QuickGO AmiGO |