Term Name: | double-strand break repair via alternative nonhomologous end joining |
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Synonyms: | A-NHEJ, alt-NHEJ, double-strand break repair via microhomology-mediated end joining, MMEJ |
Definition: | An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment. |
Ontology: | GO: Biological Process [GO:0097681] QuickGO AmiGO |