Term Name: | double-strand break repair via classical nonhomologous end joining |
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Synonyms: | C-NHEJ, canonical nonhomologous end joining |
Definition: | An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining). |
Ontology: | GO: Biological Process [GO:0097680] QuickGO AmiGO |