Term Name: extrinsic apoptotic signaling pathway
Synonyms: death receptor-mediated apoptosis, extrinsic apoptosis, extrinsic apoptotic pathway, extrinsic apoptotic signaling pathway in presence of ligand, extrinsic apoptotic signalling pathway
Definition: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
Ontology: GO: Biological Process [GO:0097191]    QuickGO    AmiGO

Relationships
has parts: death-inducing signaling complex assembly ripoptosome assembly involved in extrinsic apoptotic signaling pathway
is a type of: apoptotic signaling pathway cell surface receptor signaling pathway
has subtype: B cell receptor apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway via death domain receptors fibroblast growth factor receptor apoptotic signaling pathway
inverse has_part: ovarian follicle atresia
negatively regulated by: negative regulation of extrinsic apoptotic signaling pathway
positively regulated by: positive regulation of extrinsic apoptotic signaling pathway
regulated by: regulation of extrinsic apoptotic signaling pathway