Term Name:	G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
Synonyms:	G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate, M2 receptor signalling pathway involved in negative regulation of heart rate, muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate, muscarinic receptor signalling pathway involved in negative regulation of heart rate
Definition:	A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate.
Ontology:	GO: Biological Process [GO:0086033]    QuickGO    AmiGO