Term Name:	heteromeric SMAD protein complex
Synonyms:	SMAD1-SMAD4 protein complex, SMAD2-SMAD3-SMAD4 protein complex, SMAD2-SMAD4 protein complex, SMAD3-SMAD4 protein complex
Definition:	A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.
Ontology:	GO: Cellular Component [GO:0071144]    QuickGO    AmiGO