Term Name: | 5-methylcytosine dioxygenase activity |
---|---|
Synonyms: | methylcytosine dioxygenase activity |
Definition: | Catalysis of the reaction: 5-methylcytosine (5mC) in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine (5hmC) in DNA + succinate + CO2. This reaction is the first step in the removal of cytosine methylated on position 5 in double-stranded DNA. This activity can iteratively oxidize 5hmC to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC). |
Ontology: | GO: Molecular Function [GO:0070579] QuickGO AmiGO |