Term Name: | siRNA-mediated gene silencing by inhibition of translation |
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Synonyms: | down regulation of translation involved in RNA interference, down-regulation of translation involved in RNA interference, downregulation of translation involved in RNA interference, inhibition of translation involved in RNA interference, negative regulation of translation involved in RNA interference, RNA interference, negative regulation of translation |
Definition: | An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs. |
Ontology: | GO: Biological Process [GO:0070549] QuickGO AmiGO |