Term Name: canonical Wnt signaling pathway
Synonyms: canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway, Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Ontology: GO: Biological Process [GO:0060070]    QuickGO    AmiGO

Relationships
has parts: beta-catenin destruction complex disassembly
is a type of: Wnt signaling pathway
has subtype: canonical Wnt signaling pathway involved in heart development canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process
negatively regulated by: negative regulation of canonical Wnt signaling pathway
positively regulated by: positive regulation of canonical Wnt signaling pathway
regulated by: regulation of canonical Wnt signaling pathway