Term Name: | BH4 domain binding |
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Synonyms: | |
Definition: | Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein. |
Ontology: | GO: Molecular Function [GO:0051435] QuickGO AmiGO |