Term Name: | branched-chain alpha-keto acid dehydrogenase activity |
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Synonyms: | 2-oxoisovalerate dehydrogenase (acylating) activity, 2-oxoisovalerate dehydrogenase activity, 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating) |
Definition: | Catalysis of the reaction: [a branched-chain alpha-keto acid] + CoA + NAD+ = [a branched-chain acyl-CoA] + CO2 + NADH. This enzyme system catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. |
Ontology: | GO: Molecular Function [GO:0047101] QuickGO AmiGO |