Term Name: | oxoglutarate dehydrogenase complex |
---|---|
Synonyms: | alpha-ketoglutarate dehydrogenase complex, dihydrolipoamide S-succinyltransferase complex, KGDHC |
Definition: | A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. |
Ontology: | GO: Cellular Component [GO:0045252] QuickGO AmiGO |