Term Name:	isotype switching
Synonyms:	class switch recombination, class switching, isotype switch recombination
Definition:	The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Ontology:	GO: Biological Process [GO:0045190]    QuickGO    AmiGO