Term Name: | retroviral integrase activity |
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Synonyms: | |
Definition: | Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism. |
Ontology: | GO: Molecular Function [GO:0044823] QuickGO AmiGO |