Term Name: | NADPH oxidase complex |
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Synonyms: | flavocytochrome b558, respiratory-burst oxidase |
Definition: | A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires the cytosolic regulatory subunits at least NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2 for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. |
Ontology: | GO: Cellular Component [GO:0043020] QuickGO AmiGO |