Term Name: | MHC class I peptide loading complex |
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Synonyms: | peptide-loading complex, PLC |
Definition: | A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. |
Ontology: | GO: Cellular Component [GO:0042824] QuickGO AmiGO |