Term Name: | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity |
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Synonyms: | inhibition of host interferon regulatory factor-7 by virus, inhibition of host IRF7 by virus, suppression by virus of host interferon regulatory factor 7 activity, suppression by virus of host IRF7 activity, suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity |
Definition: | A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. |
Ontology: | GO: Biological Process [GO:0039557] QuickGO AmiGO |