Term Name: | ERBB2-ERBB3 signaling pathway |
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Synonyms: | ERBB2-ERBB3 signalling pathway, HER2-HER3 signaling pathway |
Definition: | The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission. |
Ontology: | GO: Biological Process [GO:0038133] QuickGO AmiGO |