Term Name: | ERBB2 signaling pathway |
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Synonyms: | ERBB2 signalling pathway, HER2 signaling pathway, NEU signaling, receptor tyrosine-protein kinase erbB-2 signaling pathway |
Definition: | The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. |
Ontology: | GO: Biological Process [GO:0038128] QuickGO AmiGO |