Term Name: | TCR signalosome |
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Synonyms: | LAT signalosome, linker for activation of T cells signalosome |
Definition: | A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology. |
Ontology: | GO: Cellular Component [GO:0036398] QuickGO AmiGO |