Term Name: | RNA N6-methyladenosine methyltransferase complex |
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Synonyms: | m(6)A writer complex, m6A methyltransferase complex, METTL3-METTL14-WTAP methyltransferase complex, MIS complex, Mum2, Ime4, and Slz1 complex, WMM complex |
Definition: | A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B). |
Ontology: | GO: Cellular Component [GO:0036396] QuickGO AmiGO |