Term Name: | transcription factor AP-1 complex |
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Synonyms: | Activating protein 1 complex, AP-1 complex, AP1 complex, transcription factor AP1 complex |
Definition: | A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes. |
Ontology: | GO: Cellular Component [GO:0035976] QuickGO AmiGO |