Term Name: | beta-catenin destruction complex |
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Synonyms: | 23S APC complex, APC-Axin-1-beta-catenin complex, Axin-APC-beta-catenin-GSK3B complex, BDC, beta-catenin degradation complex |
Definition: | A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. |
Ontology: | GO: Cellular Component [GO:0030877] QuickGO AmiGO |