Term Name: | NuRD complex |
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Synonyms: | Mi-2 complex, NRD complex, nucleosome remodeling and histone deacetylation complex |
Definition: | An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. |
Ontology: | GO: Cellular Component [GO:0016581] QuickGO AmiGO |