Term Name: | core-binding factor complex |
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Synonyms: | AML1 complex, CBF complex, PEPB2 complex |
Definition: | A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit. |
Ontology: | GO: Cellular Component [GO:0016513] QuickGO AmiGO |