Term Name: | inward rectifying potassium channel |
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Synonyms: | ATP-sensitive potassium channel complex, inward rectifying K+ channel, KCNJ11-SUR complex, KCNJ11-SURx complex, KCNJ8-SUR complex, KCNJ8-SURx complex, Kir6-SUR complex, Kir6.1-SUR complex, Kir6.1-SURx complex, Kir6.2-SUR complex, Kir6.2-SURx complex, Kir6.x complex, Kir6.x-SURx complex |
Definition: | A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity. |
Ontology: | GO: Cellular Component [GO:0008282] QuickGO AmiGO |