Term Name: | SRP-dependent cotranslational protein targeting to membrane |
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Synonyms: | ER translocation, SRP-dependent cotranslational membrane targeting, SRP-dependent cotranslational protein-membrane targeting |
Definition: | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
Ontology: | GO: Biological Process [GO:0006614] QuickGO AmiGO |