Term Name: nucleotide-excision repair
Synonyms: intrastrand cross-link repair, NER, pyrimidine-dimer repair, DNA damage excision
Definition: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
Ontology: GO: Biological Process [GO:0006289]    QuickGO    AmiGO

Relationships
has parts: nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA damage removal nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair, DNA gap filling nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, preincision complex stabilization
is a type of: DNA repair
has subtype: global genome nucleotide-excision repair nucleotide-excision repair involved in interstrand cross-link repair pyrimidine dimer repair by nucleotide-excision repair transcription-coupled nucleotide-excision repair
regulated by: regulation of nucleotide-excision repair