Term Name: calcidiol 1-monooxygenase activity
Synonyms: 1-hydroxylase-25-hydroxyvitamin D3 activity, 25-hydroxy D3-1alpha-hydroxylase activity, 25-hydroxy vitamin D3 1-alpha-hydroxylase activity, 25-hydroxycholecalciferol 1-hydroxylase activity, 25-hydroxycholecalciferol 1-monooxygenase activity, 25-hydroxycholecalciferol 1alpha-hydroxylase activity, 25-hydroxycholecalciferol-1-hydroxylase activity, 25-hydroxyvitamin D-1 alpha hydroxylase activity, 25-hydroxyvitamin D3 1alpha-hydroxylase activity, 25-OHD-1 alpha-hydroxylase activity, calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating), cytochrome P450 CYP27B
Definition: Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+.
Ontology: GO: Molecular Function [GO:0004498]    QuickGO    AmiGO

Relationships
is part of: calcitriol biosynthetic process from calciol
is a type of: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
negatively regulated by: negative regulation of calcidiol 1-monooxygenase activity
positively regulated by: positive regulation of calcidiol 1-monooxygenase activity
regulated by: regulation of calcidiol 1-monooxygenase activity