Term Name: metalloendopeptidase activity
Synonyms: metalloendoprotease activity, metalloendoproteinase activity
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Ontology: GO: Molecular Function [GO:0004222]    QuickGO    AmiGO

Relationships
is a type of: endopeptidase activity metallopeptidase activity
has subtype: metalloendopeptidase activity involved in amyloid precursor protein catabolic process
negatively regulated by: metalloendopeptidase inhibitor activity negative regulation of metalloendopeptidase activity
positively regulated by: positive regulation of metalloendopeptidase activity
regulated by: regulation of metalloendopeptidase activity